Effects of Macrogol 400 on Cellulose Membrane Permeation of Ethylaminobenzoate

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  • アミノ安息香酸エチルのセルロース膜透過におよぼすマクロゴール400の影響
  • アミノ アンソクコウサン エチル ノ セルロース マク トウカ ニ オヨボス

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Abstract

To clarify the diffusional behaviors of benzocaine in the presence of macrogol 400 (PEG), viscosity, solubility and cellulose membrane permeation rate of benzocaine were determined with PEG solutions of various concentrations. With an increase in PEG concentration, permeation rates of benzocaine from solutions (benzocaine conc. <solubility) decreased due to an increase in viscosity of the solution. From suspensions (benzocaine conc. >solubility), however, permeation rates increased due to an increase in benzocaine solubility.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 101 (4), 368-373, 1981

    The Pharmaceutical Society of Japan

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