Effect of Propolis on Insulin Resistance in Fructose-drinking Rats

DOI IR Web Site Web Site 5 Citations 37 References
  • ZAMAMI Yoshito
    Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
  • TAKATORI Shingo
    Pharmacology Department, Discovery Research Laboratories, Nippon Shinyaku Co., Ltd
  • KOYAMA Toshihiro
    Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
  • GODA Mitsuhiro
    Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
  • IWATANI Yukiko
    Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
  • DOI Shima
    Department of Research and Development, Yamada Apiculture Center, Inc.
  • KAWASAKI Hiromu
    Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University

Bibliographic Information

Other Title
  • フルクトース負荷インスリン抵抗性モデル（ラット）におけるPropolisによる インスリン抵抗性改善作用
  • フルクトース フカ インスリン テイコウセイ モデル ラット ニ オケル Propolis ニ ヨル インスリン テイコウセイ カイゼン サヨウ

Search this article

Abstract

  Propolis, a honeybee product, contains a variety of biologically active substances. The present study was designed to investigate the effects of propolis on insulin resistance induced by fructose-drinking rats (FDR; type 2 diabetic animal model). Male Wistar rats (6 weeks old) received 15% fructose solution in drinking water for 8 weeks. FDR showed significant increases in plasma levels of insulin, Homeostasis Model Assessment ratio (HOMA-R, an index of insulin resistance), body weight, and systolic blood pressure but not blood glucose levels, when compared with control rats. Brazilian propolis extract (100 and 300 mg/kg, p.o.) treatment for 8 weeks significantly decreased the plasma level of insulin, HOMA-R, and body weight, increased plasma triglyceride levels without affecting blood glucose and total cholesterol levels, and tended to decrease systolic blood pressure. In isolated and perfused mesenteric vascular beds of FDR, propolis treatment resulted in a significant reduction of sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS; 8 Hz) and tended to increase the calcitonin gene-related peptide (CGRP) nerve-mediated vasodilator response to PNS, compared with those in untreated FDR. However, propolis treatment did not significantly affect norepinephrine-induced vasoconstriction and CGRP-induced vasodilation. These results suggest that propolis could be an effective functional food to prevent the development of insulin resistance.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 127 (12), 2065-2073, 2007-12-01

    The Pharmaceutical Society of Japan

Citations (5)*help

See more

References(37)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top