Synthesis of Dibenzo [a, d] cycloheptenylacetic Acids

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  • Dibenzo[a, d]cycloheptene酢酸誘導体の合成
  • Dibenzo〔a,d〕cycloheptene酢酸誘導体の合成
  • Dibenzo a d cycloheptene サクサン ユウドウタイ ノ

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Abstract

10, 11-Dihydro-10-oxo-5H-dibenzo [a, d] cycloheptenylacetic acids (2a-c) and 11-oxo analogs (2d-f) were prepared from the corresponding diphenylmethanediacetic acids by cyclization. 2-(10, 11-Dihydro-11-oxo-5H-dibenzo [a, d] cyclohepten-2-yl) propionic acid was also prepared from its acetic acid derivative (2e) in four steps. Their antiinflammatory and ulcerogenic effects were examined. Some of them showed potent antiinflammatory activity in carrageenin rat paw edema and weaker effect than indomethacin in causing gastrointestinal lesions.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 101 (7), 614-628, 1981

    The Pharmaceutical Society of Japan

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