Role of the Nitric Oxide on Relaxation of the Human Umbilical Artery during Cooling
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- NURULLAHOĞLU ATALIK K. E.
- Department of Pharmacology, Faculty of Meram Medicine, University of Selçuk
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- NURULLAHOĞLU Z. Ü.
- Department of Biology, Faculty of Science and Art, University of Marmara
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- KILIÇ M.
- Department of Pharmacology, Faculty of Meram Medicine, University of Selçuk
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説明
In the present study, the effects of cooling (to 28°C) on the vasodilatation induced by diazoxide (10−9−3×10−4 M), isoproterenol (10−9−3×10−4 M) and magnesium sulphate (0.1-30 mM) on serotonin-pre-contracted human umbilical artery and the role of nitric oxide in these effects were analyzed. Diazoxide, isoproterenol and magnesium produced concentration-dependent relaxation of human umbilical artery precontracted with serotonin (10−6 M). During cooling, the pIC50 values and maximal responses to these agents were significantly lower than at 37°C. Cooling to 28°C in the presence of NG-nitro-L-arginine methyl ester (L-NAME, 10−4 M) did not modify the effects of temperature on diazoxide, isoproterenol and magnesium-induced relaxations. These results suggest that cooling-induced changes of diazoxide, isoproterenol, and magnesium sulphate in human umbilical artery are independent of nitric oxide.<br>
収録刊行物
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- 薬学雑誌
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薬学雑誌 131 (5), 661-667, 2011-05-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001206127005056
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- NII論文ID
- 130000678848
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 11112086
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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