Effect of Kampo Medicines on the Peripheral Blood Flow Rate of Betamethason-Induced Oketsu Syndrome Mice by Laser Doppler Flow Meter

  • UEDA Joji
    Department of Phytochemistry, Tohoku Pharmaceutical University
  • OHYA Etsuko
    Department of Phytochemistry, Tohoku Pharmaceutical University
  • UDAGAWA Kozue
    Department of Phytochemistry, Tohoku Pharmaceutical University
  • HARA Akiko
    Department of Phytochemistry, Tohoku Pharmaceutical University
  • FUKUI Mai
    Department of Phytochemistry, Tohoku Pharmaceutical University
  • YAMAGISHI Hirokazu
    Department of Phytochemistry, Tohoku Pharmaceutical University
  • NAKAZAWA Takahiro
    Department of Phytochemistry, Tohoku Pharmaceutical University
  • YASUDA Takaaki
    Department of Phytochemistry, Tohoku Pharmaceutical University
  • OHSAWA Keisuke
    Department of Phytochemistry, Tohoku Pharmaceutical University

Bibliographic Information

Other Title
  • レーザードップラー血流量計を用いたベタメタゾン誘発於血マウスの末梢血流量に対する漢方湯液の影響
  • レーザードップラー血流量計を用いたベタメタゾン誘発〔オ〕血マウスの末梢血流量に対する漢方湯液の影響
  • レーザードップラー ケツ リュウリョウケイ オ モチイタ ベタメタゾン ユウハツ オケツ マウス ノ マッショウケツ リュウリョウ ニ タイスル カンポウ トウエキ ノ エイキョウ

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Description

Stagnation of peripheral blood flow is the cause of various diseases. Changes in peripheral blood flow after oral administration of Kampo medicines in mice with betamethasone-induced oketsu syndrome and normal mice were examined using a laser Doppler blood flow meter. The Kampo medicines used were: Toki-shakuyaku-san; Kami-shoyo-san; Keishi-bukuryo-gan; Daio-botanpi-to; Tokaku-joki-to; Goshuyu-to; and Hange-koboku-to. In the oketsu mice, blood flow was improved by single-dose administration of Toki-shakuyaku-san, Kami-shoyo-san, Keishi-bukuryo-gan, Daio-botanpi-to, Tokaku-joki-to, and Goshuyu-to, but only Toki-shakuyaku-san increased blood flow significantly in normal mice. In addition, blood flow decreased after single-dose administration of Keishi-bukuryo-gan, Daio-botanpi-to, and Tokaku-joki-to in normal mice.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 124 (6), 365-369, 2004-06-01

    The Pharmaceutical Society of Japan

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