Vacuolar H<sup>+</sup>-ATPase and the Secondary Transporters: Their Identification, Mechanism, Function and Physiological Relevance

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  • Moriyama Yoshinori
    Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University

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Other Title
  • 液胞型H<sup>+</sup> 輸送性ATPaseと二次性トランスポーター群の構造・機能・生理的意義に関する研究
  • 液胞型H⁺輸送性ATPaseと二次性トランスポーター群の構造・機能・生理的意義に関する研究
  • エキホウガタ H ⁺ ユソウセイ ATPase ト ニジセイ トランスポーターグン ノ コウゾウ ・ キノウ ・ セイリテキ イギ ニ カンスル ケンキュウ

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Abstract

  Eukaryotic cells possess acidic compartments with pH ranging from 0.1-6.5. Studies in the last couple of decades indicated that the acid pool is established by vacuolar proton ATPase, and is essential for various physiological and pathological processes. I have identified the vacuolar ATPase as well as several secondary transporters which are energetically coupled with vacuolar ATPase. I have also established the protocol for analysis of the structure and function of transporter proteins applicable to essentially all known transporters. In this article, I am going to summarize this study and describe some topics.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 135 (7), 883-894, 2015-07-01

    The Pharmaceutical Society of Japan

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