Establishment of a Novel Therapeutic Strategy for Heart Failure Based on the Mechanism Underlying Maintenance of Redox Homeostasis by Reactive Sulfur Species

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  • Nishida Motohiro
    Division of Cardiocirculatory Signaling, Okazaki Institute for Integrative Bioscience (National Institute for Physiological Sciences), National Institutes of Natural Sciences The Graduate University for Advanced Studies (Sokendai) PRESTO, Japan Science and Technology Agency (JST) Department of Translational Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University
  • Toyama Takashi
    Division of Cardiocirculatory Signaling, Okazaki Institute for Integrative Bioscience (National Institute for Physiological Sciences), National Institutes of Natural Sciences Environmental Biology Laboratory, Faculty of Medicine, University of Tsukuba
  • Kumagai Yoshito
    Environmental Biology Laboratory, Faculty of Medicine, University of Tsukuba
  • Numaga-Tomita Takuro
    Division of Cardiocirculatory Signaling, Okazaki Institute for Integrative Bioscience (National Institute for Physiological Sciences), National Institutes of Natural Sciences The Graduate University for Advanced Studies (Sokendai)

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Other Title
  • 活性硫黄種によるレドックス恒常性維持機構に基づいた新規心不全治療戦略の構築
  • Symposium Reviews 活性硫黄種によるレドックス恒常性維持機構に基づいた新規心不全治療戦略の構築
  • Symposium Reviews カッセイ イオウシュ ニ ヨル レドックス コウジョウセイ イジ キコウ ニ モトズイタ シンキ シンフゼン チリョウ センリャク ノ コウチク

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Abstract

  Cardiac redox homeostasis is precisely regulated by reactive oxygen species (ROS) or electrophilic molecules that are formed by ROS reacting with intracellular substrates, and their eliminating systems. We have focused on the role of nitric oxide (NO) generated from inducible NO synthase (iNOS) that is continuously upregulated from early stage of heart failure, and revealed that iNOS-derived NO acts as a protective factor in the early stage of heart failure, whereas it contributes to induction of cardiac early senescence in later stages. The switching mechanism of NO-mediated signaling includes formation of endogenous NO-derived electrophilic byproducts such as 8-nitroguanosine 3′,5′-cyclic monophosphate (8-nitro-cGMP), which selectively targets an oncogenic small GTPase H-Ras at Cys-184, leading to cardiac cell senescence via covalent modification (S-guanylation) and activation of H-Ras. We also found that hydrogen sulfide-related reactive sulfur species (RSS) function as potent nucleophiles to eliminate electrophilic modification of H-Ras and suppress the onset of chronic heart failure after myocardial infarction. Our results strongly suggest a new concept of redox biology in which suppression of electrophilic irreversible modification of protein cysteine thiols by RSS may be a new therapeutic strategy of cardiovascular diseases.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 134 (12), 1239-1243, 2014-12-01

    The Pharmaceutical Society of Japan

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