書誌事項
- タイトル別名
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- Effects of 15-day Chronic Stress on Behavior and Neurological Changes in the Hippocampus of ICR Mice
- 15ニチカン ノ ストレス フカ ガ ICR マウス ニ オヨボス コウドウ ト ノウ カイバ シンケイ サイボウ エ ノ エイキョウ
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Numerous rodent models of depression have been reported, most requiring a long experimental period and significant effort. We explored a new potential mouse model for depression by investigating whether exposure to a 15-day chronic stress paradigm could induce depression-like behavior in ICR mice. Animals in the stress-exposed groups were subjected to 3 h of restraint while immersed in a 28°C water bath daily for 15 consecutive days. Immobility time in the forced swim test was increased in the chronic stress-exposed mice compared with the controls. Serum corticosterone levels were also much higher in the stressed mice than in the control mice. Hippocampal cell survival (BrdU-positive cells) and neurotrophic factor (NGF, TrkA) mRNA levels were significantly decreased in the chronic stress-exposed mice compared with controls. Administration of the anti-depressant drugs clomipramine (20 mg/kg/d) or imipramine (30 mg/kg/d) did not change the immobility time in the forced swim test, but treatment with lithium (100 mg/kg/d) did result in slight improvement. These results suggest that this 15-day chronic stress paradigm can induce depression-like behavior and neurological changes, in a short time and with minimal effort, facilitating the assessment of treatments for depression.<br>
収録刊行物
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- 薬学雑誌
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薬学雑誌 135 (1), 151-158, 2015-01-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001206127240576
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- NII論文ID
- 130004756467
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 026004753
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- PubMed
- 25743912
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可