5-(3-Aryloxypropyl)-1-cyclohexyltetrazole類の合成と血小板凝集抑制作用について

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タイトル別名
  • Synthesis of 5-(3-Aryloxypropyl)-1-cyclohexyltetrazoles and Their Inhibition of Blood Platelet Aggregation
  • 5 3 Aryloxypropyl 1 cyclohexyltetrazole

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説明

A series of 5-(3-aryloxypropyl)-1-cyclohexyltetrazoles was synthesized and tested for inhibitory activity towards collagen- and adenosinediphosphate-induced aggregation of rabbit blood platelet in vitro. These compounds were prepared by the reaction of 1-cyclohexyl-5-(3-iodopropyl)-tetrazole with phenols in the presence of a base. Among them, 6-[3-(1-cyclohexyl-5-tetrazolyl) propoxy]-1, 3-dihydro-1-ethyl-2H-benzimidazol-2-one (IVd) was found to have potent inhibitory activity. The structure-activity relationships are discussed.

収録刊行物

  • 薬学雑誌

    薬学雑誌 104 (2), 152-156, 1984

    公益社団法人 日本薬学会

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