Protective Effects of Matrine and Oxymatrine on Stress Ulcer in Relation to Their Effects on the Central Nervous System

YAMAZAKI MIKIO, ARAI AMY, SUZUKI SHIGETOSHI, TAKEUCHI TETSUO

doi:10.1248/yakushi1947.104.3_293

Matrine and oxymatrine, major components of Sophora flavescens, were previously reported to have a protective effect on restraint and water immersion stress ulcer in mice. Oxymatrine inhibits the formation of some experimental gastric ulcers, pylorus ligation ulcer and indomethacin ulcer, which are considered to relate to acid secretion. Oxymatrine decreases acid secretion in Shay's rats and inhibits gastric motility induced by restraint and water immersion stress when administered intraduodenally. These results suggest that the protective effect of oxymatrine on stress ulcer is possibly due to a decrease of acid secretion and inhibition of gastric motility. In spite of its weak inhibition of gastric acid secretion, intravenous injection of matrine is rather effective for stress ulcer. Matrine exhibits the inhibition of writhing induced by acetic acid, prolongation of sleeping time induced by pentobarbital, hypothermia and inhibition of locomotor activity induced by methamphetamine. Matrine (i.v.) also inhibits gastric motility induced by restraint and water immersion stress. These results suggest that protective effect of matrine on stress ulcer is possibly related to the effect on the central nervous system.

Protective Effects of Matrine and Oxymatrine on Stress Ulcer in Relation to Their Effects on the Central Nervous System

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