ポリエチレングリコール修飾リポソーム投与時に生ずる Accelerated Blood Clearance (ABC）現象

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  • 石田 竜弘
    徳島大学大学院ヘルスバイオサイエンス研究部薬物動態制御学分野
  • 際田 弘志
    徳島大学大学院ヘルスバイオサイエンス研究部薬物動態制御学分野

書誌事項

タイトル別名
  • Accelerated Blood Clearance (ABC) Phenomenon Induced by Administration of PEGylated Liposome
  • ポリエチレン グリコール シュウショク リポソーム トウヨジ ニ ショウズル Accelerated Blood Clearance ABC ゲンショウ

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抄録

  PEGylated liposomes (approximately 100 nm in diameter) lose their long-circulating characteristic upon repeated injection at certain intervals in the same animal (referred to as the “accelerated blood clearance (ABC) phenomenon”), as described by our group and by researchers in the Netherlands. Recently, it was demonstrated by our group that anti-PEG IgM, induced by the first dose of PEGylated liposomes, is responsible for the ABC phenomenon. The IgM produced in this manner then selectively bound to the surface of subsequently injected PEGylated liposomes, leading to substantial complement activation. It is generally believed that nanocarriers coated with a polymer, such as PEG, have no immunogenicity. However, unexpected immune responses occurred even in response to polymer-coated liposomes. This immunogenicity to PEGylated liposomes presents a serious concern in the development and clinical use of liposomal formulations. In this review, we demonstrate our recent observations regarding with the ABC phenomenon against liposomes.<br>

収録刊行物

  • 薬学雑誌

    薬学雑誌 128 (2), 233-243, 2008-02-01

    公益社団法人 日本薬学会

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