Accelerated Blood Clearance (ABC) Phenomenon Induced by Administration of PEGylated Liposome

DOI DOI Web Site Web Site PubMed 3 Citations 68 References Open Access

Bibliographic Information

Other Title
  • ポリエチレングリコール修飾リポソーム投与時に生ずる Accelerated Blood Clearance (ABC）現象
  • ポリエチレン グリコール シュウショク リポソーム トウヨジ ニ ショウズル Accelerated Blood Clearance ABC ゲンショウ
  • ChemInform Abstract: Accelerated Blood Clearance (ABC) Phenomenon Induced by Administration of PEGylated Liposome

Search this article

Description

  PEGylated liposomes (approximately 100 nm in diameter) lose their long-circulating characteristic upon repeated injection at certain intervals in the same animal (referred to as the “accelerated blood clearance (ABC) phenomenon”), as described by our group and by researchers in the Netherlands. Recently, it was demonstrated by our group that anti-PEG IgM, induced by the first dose of PEGylated liposomes, is responsible for the ABC phenomenon. The IgM produced in this manner then selectively bound to the surface of subsequently injected PEGylated liposomes, leading to substantial complement activation. It is generally believed that nanocarriers coated with a polymer, such as PEG, have no immunogenicity. However, unexpected immune responses occurred even in response to polymer-coated liposomes. This immunogenicity to PEGylated liposomes presents a serious concern in the development and clinical use of liposomal formulations. In this review, we demonstrate our recent observations regarding with the ABC phenomenon against liposomes.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 128 (2), 233-243, 2008-02-01

    The Pharmaceutical Society of Japan

Citations (3)*help

See more

References(68)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top