Preparation and Evaluation of Modified Mohs Paste without Starch

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  • Taguchi Maho
    Center for Clinical Pharmacy, Yokohama University of Pharmacy Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University
  • Shigeyama Masato
    Center for Clinical Pharmacy, Yokohama University of Pharmacy Laboratory of Clinical Pharmaceutics, Yokohama University of Pharmacy
  • Ito Nahomi
    Laboratory of Pharmaceutical Engineering, Aichi Gakuin University
  • Ogawa Noriko
    Laboratory of Pharmaceutical Engineering, Aichi Gakuin University
  • Takahashi Chisato
    Laboratory of Pharmaceutical Engineering, Aichi Gakuin University
  • Murata Mikio
    Center for Clinical Pharmacy, Yokohama University of Pharmacy Laboratory of Pharmaceutics, Yokohama University of Pharmacy
  • Hanioka Nobumitsu
    Laboratory of Biochemical Toxicology, Yokohama University of Pharmacy
  • Yamamoto Hiromitsu
    Laboratory of Pharmaceutical Engineering, Aichi Gakuin University
  • Teramachi Hitomi
    Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University

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Other Title
  • デンプン非含有Mohsペーストの調製と製剤評価
  • デンプン ヒガンユウ Mohs ペースト ノ チョウセイ ト セイザイ ヒョウカ

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Abstract

 Mohs paste is an external preparation containing zinc hydrochloride and zinc oxide starch as the main ingredient, and it is used for the palliative treatment of patients with surgically untreatable malignant tumors. However, it has problems, such as changes in hardness and viscoelasticity with time and liquefaction by exudate. To overcome these problems, we modified the formulation of Mohs paste by excluding starch, which is the cause of physical changes, and investigated the base. In the modified Mohs paste using the macrogol ointment for the base, no marked change with time was noted in the hardness, malleability, or elongation property, and the water-absorbing properties were equivalent to those of Mohs paste immediately after preparation. The hardness did not decrease even after absorbing water. The drug release rate increased 1.5 times with the modified Mohs paste. Based on these findings, the risk of liquefaction-associated damage of the surrounding skin decreased on using the modified Mohs paste, and preparing in advance became possible. These results suggest that the modified Mohs paste using the macrogol ointment for the base exhibits an equivalent effect for control of exudate and a high effect for tissue fixation.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 137 (4), 477-484, 2017-04-01

    The Pharmaceutical Society of Japan

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