ARTCEREB<sub>®</sub> Irrigation and Perfusion Solution for Cerebrospinal Surgery: Pharmacological Assessment Using Human Astrocytes Exposed to Test Solutions

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  • NISHIMURA Masuhiro
    Research and Development Center, Otsuka Pharmaceutical Factory, Inc.
  • DOI Kazuhisa
    Research and Development Center, Otsuka Pharmaceutical Factory, Inc.
  • ENOMOTO Riyo
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
  • LEE Eibai
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
  • NAITO Shinsaku
    Research and Development Center, Otsuka Pharmaceutical Factory, Inc.
  • YAMAUCHI Aiko
    Department of Pharmaceutical Information Science, Graduate School of Pharmaceutical Science, The University of Tokushima

Bibliographic Information

Other Title
  • アートセレブ<sub>®</sub>脳脊髄手術用洗浄灌流液：ヒトアストロサイト培養系を用いた薬理学的評価
  • アートセレブ脳脊髄手術用洗浄灌流液--ヒトアストロサイト培養系を用いた薬理学的評価
  • アートセレブ ノウ セキズイ シュジュツヨウ センジョウカンリュウエキ ヒトアストロサイト バイヨウケイ オ モチイタ ヤクリガクテキ ヒョウカ

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Abstract

  ARTCEREB® irrigation and perfusion solution (Artcereb) is a preparation intended for the irrigation and perfusion of the cerebral ventricles, and it is therefore important to evaluate the effects of Artcereb on brain cells. In vitro assessment of the effects of Artcereb in cell cultures of human fetal astrocytes was conducted in comparison with normal saline and lactated Ringer's solution. The effects of exposure to Artcereb were evaluated based on microscopic images of the mitochondria stained with rhodamine 123. The effects of exposure to Artcereb on cell function were also evaluated by quantitative analysis of mitochondrial activity based on rhodamine 123 and 3H-thymidine incorporation. Morphological changes in nuclear structure were also evaluated. The results of the present study showed that cell function in cell cultures of human astrocytes was relatively unaffected by exposure to Artcereb as compared with normal saline or lactated Ringer's solution, suggesting that Artcereb has less effect on brain cells than normal saline or lactated Ringer's solution when used for the irrigation or perfusion of the cerebral ventricles.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 129 (9), 1121-1126, 2009-09-01

    The Pharmaceutical Society of Japan

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