The Xanthine Oxidase Inhibitory Activity and Hypouricemic Effects of Crude Drugs Obtained from the Silkworm in Mice
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- Tanaka Ryuichirou
- Faculty of Pharmaceutical Sciences, Setsunan University
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- Miyata Yuuma
- Faculty of Pharmaceutical Sciences, Setsunan University
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- Minakuchi Naoki
- Faculty of Pharmaceutical Sciences, Setsunan University
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- Murakami Ayako
- Faculty of Pharmaceutical Sciences, Setsunan University
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- Sakazaki Fumitoshi
- Faculty of Pharmacy, Osaka Ohtani University
Bibliographic Information
- Other Title
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- 家蚕関連天然資源のXOD阻害活性とマウス血漿尿酸値低下作用
- カサン カンレン テンネン シゲン ノ XOD ソガイ カッセイ ト マウス ケッショウ ニョウサンチ テイカ サヨウ
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Abstract
This study evaluated the effects of crude drugs obtained from the silkworm in mice with oxonic acid-induced hyperuricemia using xanthine oxidase inhibitory activity and plasma uric acid levels. The plasma uric acid level was analyzed using an improved HPLC with UV detection (HPLC-UV) method, which enabled high-sensitivity analysis of a microliter of plasma. Using this method, we evaluated natural products administered orally to the hypouricemic mice. The plasma uric acid level of mice administered a water-soluble extract from silkworm larvae with botrytis (used in traditional Chinese medicine to reduce wind, lower blood pressure, and change platelet coagulation) was significantly lower than in the control group 1, 2, and 3 h after treatment. In addition, water soluble extracts from a fungus (NBRC 31161) metabolite and silkworm pupae and larvae reduced the plasma uric acid levels in mice compared with the control group.<br>
Journal
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- YAKUGAKU ZASSHI
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YAKUGAKU ZASSHI 135 (10), 1169-1176, 2015-10-01
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390001206127568000
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- NII Article ID
- 130005100633
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- NII Book ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL BIB ID
- 026778599
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- PubMed
- 26423873
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed