New Progressing Crystallization Technology of Membrane Protein and Introduction of Pharamaceutical Innovation Value Chain

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  • INOUE Tsuyoshi
    Graduate School of Engineering Osaka University NPO BioGrid Center Kansai
  • ADACHI Hiroaki
    Graduate School of Engineering Osaka University
  • MURAKAMI Satoshi
    Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University
  • TAKANO Kazufumi
    Graduate School of Engineering Osaka University
  • MATSUMURA Hiroyoshi
    Graduate School of Engineering Osaka University
  • MORI Yusuke
    Graduate School of Engineering Osaka University
  • FUKUNISHI Yoshifumi
    National Institute of Advanced Industrial Science and Technology (AIST)
  • NAKAMURA Haruki
    NPO BioGrid Center Kansai Research Center of Structural and Functional Proteomics, Institute for Protein Research, Osaka University
  • KINOSHITA Takayoshi
    Department of Applied Biochemistry, Graduate School of Agriculture and Life Sciences, Osaka Prefecture University
  • NAKANISHI Isao
    Graduate School of Pharmaceutical Sciences, Kyoto University
  • OKUNO Yasushi
    Graduate School of Pharmaceutical Sciences, Kyoto University
  • MINAKATA Satoshi
    Graduate School of Engineering Osaka University
  • SHIMOJO Shinji
    NPO BioGrid Center Kansai Cybermedia Center, Osaka University
  • SAKATA Tsuneaki
    NPO BioGrid Center Kansai Cybermedia Center, Osaka University

Bibliographic Information

Other Title
  • 膜タンパク質の結晶化技術の新展開及び創薬バリューチェインの紹介
  • マク タンパクシツ ノ ケッショウカ ギジュツ ノ シンテンカイ オヨビ ソウヤク バリュー チェイン ノ ショウカイ

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Abstract

  We have recently established a Pharamaceutical Innovation Value Chain in collaboration with the SOSHO project (http://www.so-sho.jp) and BioGrid Project (http://www.biogrid.jp/) to accelerate new drug development. The SOSHO project provides novel crystallization technology with laser-irradiation and stirring growth methods, and the BioGrid Project is developing the software necessary for the in silico screening of promising drugs and the simulation of biological responses to proteins. In this paper, we report the recent research work on the crystallization of membrane proteins and the development of a method for in silico drug discovery.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 128 (4), 497-505, 2008-04-01

    The Pharmaceutical Society of Japan

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