Nickel-Catalyzed [2+2+2] Cocyclization and Its Application to the Synthetic Organic Chemistry
-
- SATO Yoshihiro
- Graduate School of Pharmaceutical Sciences, Hokkaido University
Bibliographic Information
- Other Title
-
- ニッケル触媒を用いた[2+2+2]環化反応の開発とその応用
- ニッケル ショクバイ オ モチイタ 2 2 2 カンカ ハンノウ ノ カイハツ ト ソノ オウヨウ
Search this article
Abstract
A nickel (0)-catalyzed asymmetric [2+2+2] cocyclization has been realized for the first time. This reaction involves conceptually new enantiotopic group selective formation of a nickelacyclopentadiene intermediate and produces an isoindoline derivative (73% ee, 78% conv. yield) and an isoquinoline derivative (54% ee, 62% yield) having benzylic chiral carbon centers. The synthesizing methods of biaryls using the nickel-catalyzed [2+2+2] cocyclization were also developed. Two ways for the synthesis of biaryl using [2+2+2] cocyclization were investigated: one method is that biaryls synthesized from alkyne having a phenyl group and 2 equivalents of acetylene, and the other method is that those were synthesized from α,ω-diyne having a phenyl group at the α-position and acetylene.
Journal
-
- YAKUGAKU ZASSHI
-
YAKUGAKU ZASSHI 121 (12), 961-969, 2001-12-01
The Pharmaceutical Society of Japan
- Tweet
Details 詳細情報について
-
- CRID
- 1390001206127689600
-
- NII Article ID
- 110003648502
-
- NII Book ID
- AN00284903
-
- COI
- 1:CAS:528:DC%2BD3MXovFWqu70%3D
-
- ISSN
- 13475231
- 00316903
-
- NDL BIB ID
- 5992403
-
- PubMed
- 11766409
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- Abstract License Flag
- Disallowed