Involvement of the Amygdala on Place Aversion Induced by Naloxone in Single-Dose Morphine-Treated Rats

DOI Web Site Web Site 97 References
  • ISHIDA Shigeru
    Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
  • SHIMOSAKA Riho
    Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
  • KAWASAKI Yoichi
    Department of Hospital Pharmacy, Okayama University Hospital
  • JIN Chunyu
    Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
  • KITAMURA Yoshihisa
    Department of Pharmaceutical Care and Health Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
  • ARAKI Hiroaki
    Division of Pharmacy, Ehime University Hospital, Shitsukawa
  • SENDO Toshiaki
    Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Department of Hospital Pharmacy, Okayama University Hospital
  • GOMITA Yutaka
    Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Department of Hospital Pharmacy, Okayama University Hospital

Bibliographic Information

Other Title
  • Morphine単回投与ラットにおけるNaloxone誘発条件付け場所嫌悪行動に対する扁桃体の関与
  • Morphine タンカイ トウヨ ラット ニ オケル Naloxone ユウハツ ジョウケン ズケ バショ ケンオ コウドウ ニ タイスル ヘントウタイ ノ カンヨ

Search this article

Abstract

  Signs characteristic of opiate withdrawal symptoms can be precipitated by an opiate antagonist after short-term infusion or even a single dose of an opiate both in humans and in animals. This phenomenon has been referred to as acute dependence. In contrast to extensive studies on chronic dependence, less is known about the neural mechanisms mediating acute dependence. It will benefit the development of appropriate therapies to facilitate opiate abstinence and reduced craving to better understand the mechanisms underlying acute opiate dependence and to determine whether there are dissociation and similarity between the early and fully developed stages of dependence. In the present study, we examined the influence of c-Fos expression in the amygdala in acquisition of conditioned place aversion (CPA) induced by naloxone-precipitated withdrawal from a single morphine exposure 24 h earlier. The effect of microinjection into the central amygdaloid nucleus (CeA) of various kinds of glutamatergic neurotransmission inhibitors was also investigated. Findings showed that CeA displayed significant increase in c-Fos expression in the acquisition of CPA. Furthermore, CPA was attenuated significantly and dose-dependently by microinjection into CeA of all glutamatergic neurotransmission inhibitors (NMDA receptor antagonist (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclo-hepten-5,10-imine maleate (MK-801), AMPA receptor antagonist 1-(4-aminophenyl)4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride (GYKI52466), metabotropic glutamate receptor antagonist (±)-α-methyl-4-carboxyphenylglycine (MCPG), and glutamate release inhibitor riluzole). These findings suggest that CeA involves the acquisition of CPA induced by naloxone-precipitated withdrawal from a single morphine exposure, and the function of the glutamatergic system projected from the amygdala to nucleus accumbens plays a facilitative role in formation of morphine dependence.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 128 (3), 395-403, 2008-03-01

    The Pharmaceutical Society of Japan

References(97)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top