血管内皮依存性因子，特に一酸化窒素と高血圧

DOI DOI NDLデジタルコレクション Web Site Web Site ほか1件をすべて表示 一部だけ表示 被引用文献4件 参考文献364件 オープンアクセス

書誌事項

タイトル別名
  • Endothelium–Derived Factors in Hypertensive Blood Vessels, Especially Nitric Oxide and Hypertension
  • ケッカン ナイヒ イゾンセイ インシ トクニ 1サンカ チッソ ト コウケツアツ
  • Endothelium‐Derived Factors in Hypertensive Blood Vessels, Especially Nitric Oxide and Hypertension
公開日
2003-07-01
資源種別
journal article
DOI
  • 10.1248/yakushi.123.495
  • 10.1002/chin.200342295
公開者
公益社団法人 日本薬学会

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説明

Endothelium–dependent relaxation (EDR) in the blood vessels of spontaneously hypertensive rats (SHR) and the role of nitric oxide (NO) in the initiation of hypertension are reviewed. EDR was impaired in blood vessels of SHR depending on age and degree of hypertension when compared with those of normotensive rats. The cause of the impairment varied among the type of blood vessels: a decrease in the production of NO and endothelium–derived relaxing factor (EDRF) and an increase in the production of endothelium–derived contracting factor (EDCF) are the main causes of the impairment in large arteries, while a decrease in endothelium–dependent hyperpolarization and increased release of EDCF are the main causes of the impairment in small arteries. Interactions among these endothelium–derived factors and changes in the interactions are also causes of impairment. Superoxide may be involved in the impairment of EDR by destroying NO. The endothelium depresses smooth muscle contraction, including spontaneous tone developed in vascular smooth muscle, and the depressing effect of the endothelium is impaired in the preparations from SHR. The endothelium of blood vessels of SHR are structurally injured as demonstrated by scanning electron microscopy. Antihypertensive treatment prevented these functional and structural changes. Chronic treatment with inhibitors of NO production in normotensive rats impaired EDR and elevated blood pressure. The impairment of EDR is a secondary change due to continued hypertension, and early initiation of antihypertensive therapy is recommended.<br>

収録刊行物

  • 薬学雑誌

    薬学雑誌 123 (7), 495-515, 2003-07-01

    公益社団法人 日本薬学会

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