Effect of Mixing Method on the Mixing Degree during the Preparation of Triturations

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  • NAKAMURA Hitoshi
    Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo
  • YANAGIHARA Yoshitsugu
    Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo
  • SEKIGUCHI Hiroko
    Department of Hospital Pharmacy, Tokyo Postal Service Agency Hospital
  • KOMADA Fusao
    Department of Drug Informatics, Faculty of Pharmaceutical Sciences, Jyosai University
  • KAWABATA Haruno
    Department of Drug Informatics, Faculty of Pharmaceutical Sciences, Jyosai University
  • OHTANI Michiteru
    Department of Hospital Pharmacy, Tokyo Postal Service Agency Hospital
  • SAITOH Yukiya
    Department of Drug Informatics, Faculty of Pharmaceutical Sciences, Jyosai University
  • KARIYA Satoru
    Department of Hospital Pharmacy, Tokyo Postal Service Agency Hospital
  • SUZUKI Hiroshi
    Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo
  • UCHINO Katsuyoshi
    Department of Hospital Pharmacy, Tokyo Postal Service Agency Hospital
  • IGA Tatsuji
    Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo

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  By using lactose colored with erythrocin, we investigated the effects of mixing methods on mixing degree during the preparation of trituration with a mortar and pestle. The extent of powder dilution was set to 4 to 64 fold in the experiments. We compared the results obtained by using two methods: (1) one-step mixing of powders after addition of diluents and (2) gradual mixing of powders after addition of diluents. As diluents, we used crystallized lactose and powdered lactose for the preparation of trituration. In the preparation of 64-fold trituration, an excellent degree of mixing was obtained, with CV values of less than 6.08%, for both preparation methods and for the two kinds of diluents. The mixing of two kinds of powders whose distributions of particle sizes were similar resulted in much better degree of mixing, with CV values of less than 3.0%. However, the concentration of principal agents in 64-fold trituration was reduced by 20% due to the adsorption of dye to the apparatus. Under conditions in which a much higher dilution rate and/or much better degree of dilution was required, it must be necessary to dilute powders with considering their physicality and to determine the concentrations of principal agents after the mixing.<br>

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  • 薬学雑誌

    薬学雑誌 124 (3), 127-134, 2004-03-01

    公益社団法人 日本薬学会

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