Antitumor activity of the procyanidins from Pinus koraiensis bark on mice bearing U14 cervical cancer

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  • LI Kun
    Department of Biological Engineering, College of Environment and Chemical Engineering, Yanshan University College of Basic Medicine, Jiamusi University
  • LI Qingwang
    Department of Biological Engineering, College of Environment and Chemical Engineering, Yanshan University School of Animal Science, Northwest A & F University
  • LI Jian
    Department of Biological Engineering, College of Environment and Chemical Engineering, Yanshan University
  • ZHANG Tao
    College of Basic Medicine, Jiamusi University
  • HAN Zhengsheng
    Department of Biological Engineering, College of Environment and Chemical Engineering, Yanshan University
  • GAO Dawei
    Department of Biological Engineering, College of Environment and Chemical Engineering, Yanshan University
  • ZHENG Fulu
    Renmin Hospital of Qinhuangdao

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タイトル別名
  • Antitumor Activity of the Procyanidins from <i>Pinus koraiensis</i> Bark on Mice Bearing U14 Cervical Cancer

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  Pinus koraiensis Bark Procyanidins Extract (PKBPE) has been used in traditional Chinese medicine for thousands of years. In this study, we determined PKBPE effect on tumor weight, SOD (superoxidate dismutase) activity, the content of MDA (malondialdehyde) through colorimetric analysis antigenic, and expression of Ki-67, p53 and Bcl-2 on mice bearing U14 cervical cancer. Treatment with PKBPE (158 and 250 mg/kg body weight, p.o.) could inhibit U14 cervical carcinoma growth up to 47.68 and 58.94%. In addition, PKBPE enhance the activity of SOD (p<0.01) and decrease MDA content. Furthermore, we also observed that PKBPE treatment significantly inhibited the expression of Ki-67, mutant p53 and Bcl-2 protein (p<0.01). The results suggested that PKBPE showed antitumor activities on U14 cervical carcinoma mice. The mechanism of PKBPE antitumor activity might be associated with free radical production inhibition and regulation of the expression of Ki-67, mutant p53 and Bcl-2 protein.<br>

収録刊行物

  • 薬学雑誌

    薬学雑誌 127 (7), 1145-1151, 2007-07-01

    公益社団法人 日本薬学会

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