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- 吉村 智之
- 京都大学化学研究所
書誌事項
- タイトル別名
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- Asymmetric Synthesis of Multi-substituted β-Lactams <i>via</i> C-N Axially Chiral Enolates in Intramolecular Conjugate Addition
- C-Nジクセイ フセイ エノラート ノ ブンシ ナイ キョウヤク フカ オ リヨウ スル タチカンv-ラクタム ノ フセイ ゴウセイ
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The synthesis of β-lactams with contiguous tetra- and trisubstituted carbon centers has been accomplished via the 4-exo-trig intramolecular conjugate addition of C-N axially chiral enolates generated from α-amino acid derivatives. Use of a metal carbonate in a protic solvent (i.e., Cs2CO3 in EtOH) was found to be critical for the success of the reaction. Under optimized reaction conditions, axially chiral enolates were generated in very low concentration, thereby favoring intramolecular conjugate addition while minimizing intermolecular side reactions. The highly strained β-lactam enolates formed through this reversible intramolecular conjugate addition were rapidly protonated by EtOH in the reaction media to afford β-lactams in up to 97% ee.<br>
収録刊行物
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- 薬学雑誌
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薬学雑誌 132 (11), 1287-1295, 2012-11-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001206128046976
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- NII論文ID
- 130001871987
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- NII書誌ID
- AN00284903
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- COI
- 1:STN:280:DC%2BC3s7gs1CgsQ%3D%3D
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 024067538
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- PubMed
- 23123721
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可