生体分子の立体構造と分子間相互作用の研究を振り返って

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タイトル別名
  • Overview of Structural Study on Conformations and Intermolecular Interactions of Biomolecules
  • セイタイ ブンシ ノ リッタイ コウゾウ ト ブンシ カン ソウゴ サヨウ ノ ケンキュウ オ フリカエッテ

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抄録

  Information on the conformational feature and specific intermolecular interaction of biomolecules is important to understand the biological function and to develop device for treating disorder caused by the abnormal function. Thus the 3D structures of the biologically active molecules and the specific interactions with their target molecules at the atomic level have been investigated by various physicochemical approaches. Herein, the following five subjects are reviewed: (1) function-linked conformations of biomolecules including natural annular products, opioid peptides and neuropeptides; (2) π-π stacking interactions of tryptophan derivatives with coenzymes and nucleic acid bases; (3) mRNA cap recognition of eukaryotic initiation factor 4E and its regulation by 4E-binding protein; (4) conformational feature of histamine H2 receptor antagonists and design of cathepsin B inhibitors; (5) self-aggregation mechanism of tau protein and its inhibition.<br>

収録刊行物

  • 薬学雑誌

    薬学雑誌 132 (7), 785-816, 2012-07-01

    公益社団法人 日本薬学会

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