書誌事項
- タイトル別名
-
- Studies on Development of the Ultra-fine Size Reduction Method of Slightly Soluble Medicinal Crystals. IV. Enhanced Bioavailability of Oxolinic Acid by Ultra-fine Size Reduction
- 難溶性医薬品結晶の超微細化方法の開発に関する研究-4-超微細化によるオキソリン酸のバイオアベイラビリティの向上
- ナンヨウセイ イヤクヒン ケッショウ ノ チョウ ビサイカ ホウホウ ノ カイ
この論文をさがす
説明
The physicochemical properties and gastrointestinal absorption of the ultra-fine size reduced oxolinic acid (OA) prepared according to the previous paper were investigated in comparison with original and mechanical pulverized crystals. It was found that there was no change in their crystal forms by powder X-ray diffraction measurement and their dissolution rates increased remarkably. Moreover, by use of this OA, a significant improvement was detected in the level of plasma concentration of OA after oral administration to dogs and the areas under the plasma concentration-time curve of them were 2.5 times the mechanical pulverized crystals.
収録刊行物
-
- 薬学雑誌
-
薬学雑誌 103 (11), 1190-1194, 1983
公益社団法人 日本薬学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001206128119424
-
- NII論文ID
- 130007274641
- 110003650420
-
- NII書誌ID
- AN00284903
-
- ISSN
- 13475231
- 00316903
-
- NDL書誌ID
- 2977178
-
- データソース種別
-
- JaLC
- NDLサーチ
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可