The Effects of Kampo-Formulation and the Constituting Crude Drugs, Prescribed for the Treatment of Peptic Ulcer on H,K-ATPase Activity

SATOH Kanako, NAGAI Fumiko, SETO Takako, YAMAUCHI Hiroshi

doi:10.1248/yakushi.121.173

Bibliographic Information

Other Title

胃疾患に繁用される漢方方剤及び構成生薬エキス, 生薬含有成分のH,K-ATPase活性に及ぼす影響
イシッカンニハンヨウサレルカンポウホウザイオヨビコウセイショウヤクエキスショウヤクガンユウセイブンノ H K ATPase カッセイニオヨボスエイキョウ

Search this article

Abstract

We studied the effects of 17 kinds of Kampo-formulations prescribed for the treatment of peptic ulcer on H,K-ATPase activity. The activity was strongly inhibited by San-o-shashin-to (IC₅₀=82 μg/ml), Bukuryo-in (IC₅₀=110 μg/ml), Shakuyaku-kanzo-to (C₅₀=170 μg/ml), Hange-koboku-to (IC₅₀=290 μg/ml), Dai-saiko-to (IC₅₀=340 μg/ml), Irei-san (IC₅₀=380 μg/ml) than other Kampo-formulations. Among the 17 kinds of crude drugs contained in these Kampo-formulation, Rhei Rhizoma, Coptidis Rhizoma, Glycyrrhiza Radix, Cinnamomi Cortex, and Poria have notable inhibitory effects (IC₅₀=19∼57 μg/ml). H,K-ATPase activity was inhibited by sennoside A (Rhei Rhizoma), sennoside B (Rhei Rhizoma), ergosterol (Poria), coptisine (Coptidis Rhizoma), glycyrrhizin (Glycyrrhiza Radix), glycyrrhetic acid (Glycyrrhiza Radix), gallic acid (Cinnamomi Cortex) in the 21 components of these crude drugs (IC₅₀=1.6∼7.9×10^-4M). The inhibition of San-o-shashin-to and Bukuryo-in is considered to be mainly attributed to Rhei Rhizoma and Poria, respectively. The anti-gastric ulcer effects of San-o-shashin-to and Bukuryo-in may be ascribed to the inhibition of H,K-ATPase activity.

Journal

YAKUGAKU ZASSHI

YAKUGAKU ZASSHI 121 (2), 173-178, 2001-02-01

The Pharmaceutical Society of Japan

Keywords

Details 詳細情報について

Export