書誌事項
- タイトル別名
-
- Vasorelaxant Activity of Caffeic Acid Derivatives from Cichorium intybus and Equisetum arvense
- キクニガナ及びスギナより得られたカフェ一酸エステルの血管平滑筋弛緩作用
- キクニガナ オヨビ スギナ ヨリ エラレタ カフェ 1サン エステル ノ ケッカン ヘイカツキン シカン サヨウ
この論文をさがす
抄録
The vasorelaxant activities of chicoric acid (Compound 1) from Cichorium intybus and dicaffeoyl-meso-tartaric acid (Compound 2) from Equisetum arvense L. in isolated rat aorta strips were studied. Compound 1 is a diester composed of (S,S)-tartaric acid and caffeic acid, and 2 is composed of its meso type. Both 1 and 2 showed slow relaxation activity against norepinephrine (NE)-induced contraction of rat aorta with/without endothelium. These compounds did not affect contraction induced by a high concentration of potassium (60 mM K+), while they inhibited NE-induced vasocontraction in the presence of nicardipine. These results show that the inhibition by 1 and 2 of NE-induced vasocontraction is due to a decrease in calcium influx from the extracellular space caused by NE. In addition, dicaffeoyl tartaric acids showed vasorelaxant activity, regardless of their stereochemistry.<br>
収録刊行物
-
- 薬学雑誌
-
薬学雑誌 123 (7), 593-598, 2003
公益社団法人 日本薬学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001206128159488
-
- NII論文ID
- 110003614907
-
- NII書誌ID
- AN00284903
-
- COI
- 1:CAS:528:DC%2BD3sXms1Gnsrw%3D
-
- ISSN
- 13475231
- 00316903
-
- NDL書誌ID
- 6635221
-
- PubMed
- 12875242
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可