-
- 室本 竜太
- 北海道大学大学院薬学研究院創薬科学部門生体機能科学分野衛生化学研究室
書誌事項
- タイトル別名
-
- Death Domain-associated Protein (DAXX)-mediated Regulation of Transcription and Cell Death
- Death domain-associated protein(DAXX)ニ ヨル テンシャ チョウセツ ト サイボウシ
この論文をさがす
抄録
Death domain-associated protein (DAXX) is a multifunctional protein that modulates both cell death and transcription. DAXX predominantly localizes in the nucleus and regulates the transcription of genes. Several studies have indicated that DAXX is a mediator of lymphocyte death and/or growth suppression, although it is still unclear whether DAXX pro-cell death function is dependent on its transcriptional functions. We found that DAXX suppresses the gp130/STAT3-dependent cell growth and that DAXX interacts with STAT3 and inhibits its DNA-binding activity. Here we will discuss recent developments in our understanding of the nuclear functions of DAXX.<br>
収録刊行物
-
- 薬学雑誌
-
薬学雑誌 132 (9), 979-984, 2012-09-01
公益社団法人 日本薬学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001206128543232
-
- NII論文ID
- 130001888732
-
- NII書誌ID
- AN00284903
-
- COI
- 1:STN:280:DC%2BC3s%2Fht1Citg%3D%3D
-
- ISSN
- 13475231
- 00316903
-
- NDL書誌ID
- 023961085
-
- PubMed
- 23023413
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可