Studies on the Conditions to Measure the Dermal Blood Flow in Anesthetized Rats Using the Thermoelectrical Elements

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  • 熱電効果による麻酔下ラットの皮膚血流測定条件の検討
  • 熱電効果による麻酔ラットの皮膚血流測定条件の検討
  • ネツデン コウカ ニヨル マスイ ラット ノ ヒフ ケツリュウ ソクテイ ジョ

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Abstract

The experimental conditions to measure accurately the changes of dermal blood flow (DBF) in rats were studied according to the thermoelectrical element method, which was uninterfered with muscle blood flow and arteriovenous shunt in the precapillary regions. Main factors affecting the stability and the sensitivity to drugs of DBF were the body weight and the treatment to immerse into the water bath. The most suitable conditions were as follows. 1. The body weight was 245-257g. 2. The anesthetized rats were immersed into the water bath at 15°C to the depth of xiphoid process for 10 min. Under these conditions, the changes of DBF by the application of the reference drugs (norepinephrine, dl-α-tocopheryl nicotinate, inositol hexanicotinate, isoxsuprine hydrochloride) were measured accurately.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 103 (9), 1001-1005, 1983

    The Pharmaceutical Society of Japan

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