4 種類のリドカイン製剤（院内製剤）における基剤の検討

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タイトル別名
  • The Base in Four Types of Lidocaine Preparation (Formulated in Hospital)
  • 4シュルイ ノ リドカイン セイザイ(インナイ セイザイ)ニ オケル キザイ ノ ケントウ

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  PL cream (combination of lidocaine and procaine) was launched on the market in April 2012 in Japan. We investigated differences in the anesthetic effect by employing two types of base: Carbopol and methylcellulose. Electron microscopy showed a distinct difference in appearance: densely-scattered, fine particles for Carbopol and sparse, large particles for methylcellulose. Accordingly, the extensibility of the cream was significantly greater at 4 and 25 degrees centigrade for methylcellulose, but was greater at 34 degrees centigrade for Carbopol. The steady flow viscosity (1 s−1) was greater for the Carbopol than methylcellulose base. The difference in the cutaneous permeability between the two bases increased over time: the methylcellulose base was removed at 90 min after application and, 30 min later, showed a significant difference. These results suggest that the methylcellulose base has a superior anesthetic effect in clinical settings.<br>

収録刊行物

  • 薬学雑誌

    薬学雑誌 134 (2), 249-258, 2014-02-01

    公益社団法人 日本薬学会

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