HPLC-Method for Deliberation of Drug Mammary Transfer<br/>—Evaluation of Over-the-Counter Drugs (Loxonin<sup>®</sup>-S, Bufferin<sup>®</sup> A) in Mother Mice
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- Komori Koji
- Department of Medical Pharmacy, Faculty of Pharmaceutical Sciences, Setsunan University
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- Komae Ryohei
- Department of Medical Pharmacy, Faculty of Pharmaceutical Sciences, Setsunan University
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- Yamazaki Yuki
- Department of Medical Pharmacy, Faculty of Pharmaceutical Sciences, Setsunan University
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- Nakano Shoko
- Department of Medical Pharmacy, Faculty of Pharmaceutical Sciences, Setsunan University
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- Mitamura Shinobu
- Department of Medical Pharmacy, Faculty of Pharmaceutical Sciences, Setsunan University
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- Miyazaki Tamami
- Department of Medical Pharmacy, Faculty of Pharmaceutical Sciences, Setsunan University
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- Kikuta Maho
- Department of Medical Pharmacy, Faculty of Pharmaceutical Sciences, Setsunan University
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- Takada Masahiro
- Department of Medical Pharmacy, Faculty of Pharmaceutical Sciences, Setsunan University
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- Shuto Makoto
- Department of Medical Pharmacy, Faculty of Pharmaceutical Sciences, Setsunan University
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- Hane Yumiko
- Department of Medical Pharmacy, Faculty of Pharmaceutical Sciences, Setsunan University
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- Yamamoto Toshiko
- Department of Medical Pharmacy, Faculty of Pharmaceutical Sciences, Setsunan University
Bibliographic Information
- Other Title
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- 薬物の乳汁移行性を検討するためのHPLCを用いた一手法<br/>—泌乳マウスを用いた一般用医薬品(ロキソニン<sup>®</sup>-S錠,バファリン<sup>®</sup>A錠)の検討
- 薬物の乳汁移行性を検討するためのHPLCを用いた一手法 : 泌乳マウスを用いた一般用医薬品(ロキソニン-S錠,バファリンA錠)の検討
- ヤクブツ ノ ニュウジュウ イコウセイ オ ケントウ スル タメ ノ HPLC オ モチイタ イチシュホウ : ヒニュウマウス オ モチイタ イッパンヨウ イヤクヒン(ロキソニン-Sジョウ,バファリン Aジョウ)ノ ケントウ
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Abstract
Loxoprofen (Loxonin®), an antipyretic painkiller, was approved as an over-the-counter (OTC) drug (Loxonin®-S) in January 2011. With regard to self-medication using OTC drugs, the information that pharmacists provide to consumers is very important. Although loxoprofen is a very versatile drug and can be used during breastfeeding, information regarding its mammary gland transfer is inadequate. In this study, we established a simple method to evaluate mammary transfer of drugs, and compared loxoprofen's mammary gland transfer with that of aspirin. Loxoprofen 12 mg/kg and aspirin 132 mg/kg was orally administered to mother mice (ddY), and blood and milk samples were collected. Twenty microliters of ethanol was added to the blood and milk samples (10 μL), and the mixture was centrifuged for 15 min (12000 g); the supernatant was analyzed by high-performance liquid chromatography. Since aspirin was immediately metabolized, we analyzed salicylic acid concentrations. Maximum concentration of loxoprofen was observed at around 15 min after its oral administration, with the concentrations in the blood and milk being 2.9 and 0.5 μg/mL, respectively. The drug was metabolized promptly thereafter. In contrast, maximum concentration of salicylic acid was observed at 30 min after aspirin administration, with the concentrations in the blood and milk being 187.2 and 64.4 μg/mL, respectively. These concentrations remained constant from 60 to 120 min. Salicylic acid could be detected 240 min after aspirin administration. Thus, mammary gland transfer of loxoprofen is lower than that of aspirin, suggesting that loxoprofen does not accumulate in milk.<br>
Journal
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- YAKUGAKU ZASSHI
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YAKUGAKU ZASSHI 133 (8), 905-911, 2013
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390001206128907648
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- NII Article ID
- 130003361974
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- NII Book ID
- AN00284903
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- COI
- 1:STN:280:DC%2BC3sflsleiuw%3D%3D
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- ISSN
- 13475231
- 00316903
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- NDL BIB ID
- 024827678
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- PubMed
- 23903231
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed