Role of Protein <i>S</i>-nitrosylation in Central Nervous System Survival and Regeneration

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  • Koriyama Yoshiki
    Department of Molecular Neurobiology, Graduate School of Medicine, Kanazawa University

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Other Title
  • 中枢神経修復・再生におけるタンパク質の<i>S</i>-ニトロシル化の役割
  • 中枢神経修復・再生におけるタンパク質のS-ニトロシル化の役割
  • チュウスウ シンケイ シュウフク ・ サイセイ ニ オケル タンパクシツ ノ S-ニトロシルカ ノ ヤクワリ

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Abstract

  The retina has been regarded as 'an approachable part of the brain' for investigating central nervous system (CNS). The optic nerve injury is a well-accepted model to study the mechanisms of neural degeneration and/or axonal regeneration after trauma in the CNS. Nitric oxide (NO) is a gaseous messenger molecule biosynthesized from L-arginine and molecular oxygen by NO synthase. Many reports suggest that excess production of NO plays a crucial role in neuronal cell death including in death of retinal ganglion cells (RGCs). In contrast, several lines of evidence indicate that NO can prevent neuronal death. In general, NO mediates neuroprotection through two main signaling pathways: the NO/cyclic guanosine monophosphate (cGMP) pathway and the S-nitrosylation pathway. Especially, whether S-nitrosylation of proteins promotes RGCs survival and its axonal regeneration after injury is unclear. Thus, we focused on the S-nitrosylation-dependent mechanism of RGCs survival and axonal regeneration by NO after nerve injury.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 133 (8), 843-848, 2013

    The Pharmaceutical Society of Japan

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