Comparative Evaluation of Coloration of Photosensitive Solid Drugs under Various Light Sources

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  • 数種の光源下における固形医薬品の着色に関する比較評価
  • スウシュ ノ コウゲンカ ニ オケル コケイ イヤクヒン ノ チャクショク ニ

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Abstract

Photostability of eight kinds of photosensitive solid drugs was evaluated from the point of coloration under various light sources such as mercury vapor lamp, daylight lamp, and two kinds of fluorescent Iamps. Sample drugs examined were sulpyrine, chlorpromazine hydrochloride, perphenazine, indomethacin, promethazine hydrochloride, imipramine hydrochloride, furosemide, and phenytoin. Coloration was determined by tristimulus colorimetry. In order to investigate the photosensitivity of these samples, their action spectra for coloration was obtained with a grating monochrometer in the range of irradiation wavelength 306-475 nm. Coloration process of each sample could be expressed as a straight line on double-log scale. These processes changed corresponding to the combination of drug and light source, indicating different coloration reaction orders. These apparent orders and the degree of coloration were discussed in relation to the action spectrum of each sample. In some of the samples the existence of photosensitive similarity in coloration between exaggerated and ordinary irradiation conditions was suggested.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 100 (9), 953-957, 1980

    The Pharmaceutical Society of Japan

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