Liquid Phase Methylation of Pyrazine and Pyridine with Ni Catalysts

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Other Title
  • ニッケル触媒によるビラジン, ビリジンの液相メチル化反応
  • ニッケル触媒によるピラジン,ピリジンの液相メチル化反応
  • ニッケル ショクバイ ニ ヨル ピラジン,ピリジン ノ エキソウ メチルカ ハンノウ

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Description

The methylation of pyrazine with methanol was carried out in the presence of Ni catalysts. Raney Ni was found to have an excellent activity for the methylation and 2-methylpyrazine was formed as a main product, with a small amount of dimethylpyrazine. By use of Raney Ni at 200°for 12hr, the yields of 2-methylpyrazine and dimethylpyrazine were 49.2 and 9.3%, respectively. Pyridine was also methylated with Raney Ni in good yield. The activity of several types of Ni catalysts was examined in the methylation of pyrazine.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 101 (1), 20-24, 1981

    The Pharmaceutical Society of Japan

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