Studies on the Compounds related to Azulene. III. Synthesis and Antiulcer Activity of Acylaminoguaiazulenes

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  • Azulene関連化合物の研究(第3報)Acylaminoguaiazulene類の合成と抗潰瘍作用
  • Azulene関連化合物の研究-3-Acylaminoguaiazulene類の合成と抗潰瘍作用
  • Azulene カンレン カゴウブツ ノ ケンキュウ 3 Acylaminog

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Abstract

Acylaminoguaiazulenes, mainly dicarboxylic acid monoguaiazulenamides, were synthesized and their antiulcer activity was investigated by Shay ulceration method in the rat. Dicarboxylic acid monoguaiazulenamides, particularly aliphatic dicarboxylic acid monoguaiazulenamides, showed a high antiulcer activity. Compounds (1g, h) were more effective than guaiazulene in both administrations (s.c. and i.d.). Structure-activity relationship of these compounds was briefly discussed.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 101 (11), 1048-1052, 1981

    The Pharmaceutical Society of Japan

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