非ステロイド性鎮痛・抗炎症薬Tolmetin Sodiumの関節炎痛, 打撲浮腫ならびにLPS発熱に対する影響

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タイトル別名
  • Effect of a Non-steroidal Anti-inflammatory Drug, Tolmetin Sodium on Arthritic Pain, Traumatic Edema and LPS-induced Fever
  • ヒ ステロイドセイ チンツウ コウ エンショウヤク Tolmetin Sodi

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Anti-inflammatory, analgesic and anti-pyretic activities of tolmetin sodium were studied in comparison with aspirin, ibuprofen and indomethacin. Analgesic ED50 value of tolmetin sodium against AgNO3-induced arthritic pain in rats was 27.2mg/kg, p.o. and the potency was about 20 times, twice and 3 times that of aspirin, ibuprofen and mefenamic acid, respectively, and about 1/3 and 1/13 times that of diclofenac sodium and indomethacin, respectively. Tolmetin sodium showed a significant therapeutic effect on traumatic hind paw edema in rats at a dose of 20mg/kg, p.o. or more, and the potency was 4 times or more that of aspirin, about the same as ibuprofen and about 1/10 times that of indomethacin. The anti-pyretic ED50 value of tolmetic sodium in adjuvantinduced febrile rats was 15.8mg/kg, p.o., and the potency was about 2.5 times that of aspirin and about 1/13 and 1/40 times that of ibuprofen and indomethacin, respectively. Tolmetin sodium showed an anti-pyretic effect on lipopolysaccharide-induced fever in rabbits at a dose of 40 mg/kg, p.o. or more, and the potency was about 3 times that of aspirin, about the same as ibuprofen and about 1/10 times that of indomethacin. These results confirm the previous results that tolmetin sodium has possessed a relatively potent inhibitory activity on inflammatory pain and acute inflammation.

収録刊行物

  • 薬学雑誌

    薬学雑誌 101 (7), 649-656, 1981

    公益社団法人 日本薬学会

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