Entry Mechanism of Morbillivirus Family

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  • Fukuhara Hideo
    Laboratory of Biomolecular Science, Faculty of Pharmaceutical Sciences, Hokkaido University
  • Chen Surui
    Laboratory of Biomolecular Science, Faculty of Pharmaceutical Sciences, Hokkaido University
  • Takeda Shin
    Laboratory of Biomolecular Science, Faculty of Pharmaceutical Sciences, Hokkaido University
  • Maenaka Katsumi
    Laboratory of Biomolecular Science, Faculty of Pharmaceutical Sciences, Hokkaido University Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University CREST, Japan Science and Technology Agency (JST)

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Other Title
  • モルビリウイルス属の細胞侵入機構
  • モルビリウイルスゾク ノ サイボウ シンニュウ キコウ

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Abstract

  The genus Morbillivirus includes measles virus, canine distemper virus and rinderpest virus. These are highly contagious and exhibit high mortality. These viruses have the attachment glycoprotein, hemagglutinin (H), at the virus surface, which bind to signaling lymphocyte activation molecule (SLAM) and Nectin 4 as receptors for the entry. However, the molecular mechanism for this entry has been limitedly understood. Here we summarize the current topics, (1) newly identified receptor, Nectin 4, (2) crystal structures of H-receptor complexes and (3) detail biochemical studies of the H-F communication for the entry. These provide insight on the mechanism of morbillivirus entry event and furthermore drug developments.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 133 (5), 549-559, 2013-05-01

    The Pharmaceutical Society of Japan

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