書誌事項
- タイトル別名
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- Structural Study of Polyglutamine Tract-binding Protein 1
- Polyglutamine tract-binding protein 1 ノ コウゾウ セイブツガクテキ ケンキュウ
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抄録
Polyglutamine tract-binding protein 1 (PQBP1) is a nuclear protein that regulates transcription and pre-mRNA splicing. In addition, the mutations in the PQBP1 gene are known to cause hereditary mental retardation. This review summarizes current knowledge about the solution structure of PQBP1. PQBP1 is an intrinsically disordered protein: its polar-rich domain and C-terminal domain are disordered under physiological conditions. PQBP1 binds to its target molecule U5-15kD via a continuous 23-residue segment of the C-terminal domain. The function of PQBP1 in the pre-mRNA splicing is also discussed.<br>
収録刊行物
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- 薬学雑誌
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薬学雑誌 133 (5), 519-526, 2013-05-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001206129132288
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- NII論文ID
- 130003361945
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- NII書誌ID
- AN00284903
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- COI
- 1:STN:280:DC%2BC3snhsVKgtQ%3D%3D
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 024650621
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- PubMed
- 23649393
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可