-
- 宝田 剛志
- 金沢大学医薬保健研究域薬学系薬物学研究室
書誌事項
- タイトル別名
-
- Signaling Factors in a Variety of Cells Derived from Mesenchymal Stem Cells
- カン ヨウケイ カン サイボウ ニ ユライ スル カクシュ サイボウ ノ キノウ セイギョ ニ カンスル ケンキュウ
この論文をさがす
抄録
L-Glutamate (Glu) and γ-aminobutyric acid (GABA) has been thought to be an excitatory/inhibitory amino acid neurotransmitter in the mammalian central nervous system (CNS). Limited information is available in the literature with regard to an extracellular transmitter role of Glu and GABA in peripheral neuronal and non-neuronal tissues, whereas recent molecular biological analyses including ours give rise to a novel function for Glu and GABA as an autocrine and/or paracrine factor in a variety of cells derived from mesenchymal stem cells, in addition to other peripheral tissues including pancreas, adrenal, and pituitary glands. Emerging evidence suggests that Glu and GABA could play a dual role in mechanisms underlying maintenance of cellular homeostasis as a neurotransmitter in the CNS and as an extracellular signal mediator in peripheral autocrine and/or paracrine tissues. In this review, therefore, we summarized the possible signaling by Glu and GABA as an extracellular signal mediator in mechanisms underlying maintenance of cellular homeostasis in mesenchymal stem cells, osteoblasts and chondrocytes.<br>
収録刊行物
-
- 薬学雑誌
-
薬学雑誌 132 (10), 1145-1149, 2012-10-01
公益社団法人 日本薬学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001206129254912
-
- NII論文ID
- 130001871971
-
- NII書誌ID
- AN00284903
-
- COI
- 1:STN:280:DC%2BC3s%2Fis1Cmsg%3D%3D
-
- ISSN
- 13475231
- 00316903
-
- NDL書誌ID
- 024020493
-
- PubMed
- 23037699
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可