A Comparative Study of the Usefulness of Toki-shakuyaku-san and An Oral Iron Preparation in the Treatment of Hypochromic Anemia in Cases of Uterine Myoma

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  • AKASE Tomoko
    <i>Department of Clinical and Biomedical Sciences, Showa Pharmaceutical University</i>
  • AKASE Tomohide
    <i>Department of Clinical and Biomedical Sciences, Showa Pharmaceutical University</i> <i>Graduate School of Business, Nihon University</i>
  • ONODERA Satoshi
    <i>Department of Clinical and Biomedical Sciences, Showa Pharmaceutical University</i>
  • JOBO Toshiko
    <i>Department of Gynecology, Kitasato University School of Medicine</i>
  • MATSUSHITA Ryo
    <i>Division of Pharmacy and Health Sciences, Graduate School of Natural Science and Technology, Kanazawa University</i>
  • KANEKO Masakazu
    <i>Department of Clinical Pharmacology and Therapeutics, Ehime University School of Medicine</i>
  • TASHIRO Shin-ichi
    <i>Department of Clinical and Biomedical Sciences, Showa Pharmaceutical University</i>

書誌事項

タイトル別名
  • A Comparative Study of the Usefulness of <i>Toki-shakuyaku-san</i> and An Oral Iron Preparation in the Treatment of Hypochromic Anemia in Cases of Uterine Myoma
  • Comparative Study of the Usefulness of Toki shakuyaku san and An Oral Iron Preparation in the Treatment of Hypochromic Anemia in Cases of Uterine Myoma

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説明

We prospectively studied and compared the usefulness of Kampo medicine (Sino-Japanese traditional herbal medicine) “Toki-shakuyaku-san” and an oral iron preparation in the treatment of hypochromic anemia associated with uterine myoma. The study subjects consisted of 25 patients who were diagnosed as having hypochromic mild to moderate anemia associated with menorrhagia attributable to uterine myoma. They were divided into the Toki-shakuyaku-san group (n=10) and the oral iron group (n=15). We monitored the blood counts, subjective symptoms, and occurrence of side effects after oral administration of either preparation for 4 and 8 weeks in these subjects. In regard to the blood counts and improvement of the laboratory parameters of anemia, while marked improvement was observed in the oral iron group, no significant improvement was noted in the Toki-shakuyaku-san group. On the other hand, in terms of improvement of the signs and symptoms of anemia, such as facial pallor, spoon-shaped nails and dizziness, the latter group also showed significant improvement. In addition in the Toki-shakuyaku-san group, resolution of symptoms such as hypermenorrhea, dysmenorrhea, feeling cold, dizziness, headache and shoulder stiffness was also noted. While side effects were encountered in 80.0% of patients in the oral iron group, no significant side effects were observed in the Toki-shakuyaku-san group. From these findings, it is considered that Toki-shakuyaku-san may be useful for resolving the symptoms of mild or moderate anemia associated with uterine myoma.<br>

収録刊行物

  • 薬学雑誌

    薬学雑誌 123 (9), 817-824, 2003-09-01

    公益社団法人 日本薬学会

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