Transdermal Penetration and Biodistribution of Nanomaterials and Their Acute Toxicity <i>in Vivo</i>

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  • TSUNODA Shin-ichi
    Laboratory of Biopharmaceutical Research, National Institute of Biomedical Innovation

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  • ナノマテリアルの皮膚透過性・体内動態と急性毒性
  • ナノマテリアル ノ ヒフ トウカセイ タイナイ ドウタイ ト キュウセイ ドクセイ

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  Recently, the number of applications of nanomaterials in medicine, cosmetics and food to which we are directly exposed has been expanding rapidly. The safety of such nanomaterials has not been well assessed, because nanomaterials have been considered as safe as common larger sized materials which are known not to be absorbed by the body. Therefore, WHO and OECD are collecting safety information on nanomaterials with a view to regulation of their use. Although assessment of in vivo behaviors of nanomaterials, (i.e., absorption and distribution, and correlation analysis with hazard information) is urgently needed, such research has not yet been undertaken. In this regard, using amorphous silica particles as model nanomaterials, we are starting to study safety, in vivo behavior and their correlation; silica particles are often used in cosmetics and foods and also, downsized particles are rapidly becoming available. In our study, we have found that silica particles below 100 nm in diameter show significantly different characteristics in in vivo behavior and biological effects i.e., penetration through skin and distribution to brain. Here, I addressed the importance of studies in physicochemical characteristics, kinetic behaviors, and biological effects of nanomaterials below 100 nm in size, to ensure their safety.<br>

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  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 131 (2), 203-207, 2011-02-01

    The Pharmaceutical Society of Japan

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