-
- 岡田 欣晃
- 大阪大学大学院薬学研究科生命情報解析学分野
書誌事項
- タイトル別名
-
- Regulation of Endothelial Cell-specific Robo4 Gene Expression by DNA Methylation and Non-lineage Specific Transcription Factors
- ケッカン ナイヒ サイボウ トクイテキ ニ Robo4 イデンシ ガ ハツゲン スル メカニズム ノ カイメイ
この論文をさがす
抄録
Studies of tissue-specific gene expression have suggested that tissue-specific transcription factors or tissue-specific combinations of non-cell-type-specific transcription factors regulate tissue-specific gene expression. Although the studies of endothelial cell (EC)-specific gene expression has identified several transcriptional activators such as SP1, ETS family proteins, and GATA proteins, their expression and combinations are not likely to be EC-specific. To investigate the mechanism of EC-specific gene expression, we analyzed the regulation mechanism of an EC-specific gene, Roundabout4 (Robo4). We identified the 3-kb Robo4 promoter and several transcription factors including SP1 and GABP that bind to the Robo4 promoter and promote Robo4 gene expression. However, we could not explain the mechanism for EC-specific Robo4 gene expression with only those factors because their expression and combination are not EC-specific. Therefore, we hypothesized the contribution of other mechanisms, especially epigenetic control, to Robo4 gene regulation and demonstrated the importance of DNA methylation for EC-specific Robo4 expression. In this review, we summarize our recent studies and discuss the novel regulation model of Robo4 gene expression by transcription factors and DNA methylation.<br>
収録刊行物
-
- 薬学雑誌
-
薬学雑誌 134 (7), 817-821, 2014-07-01
公益社団法人 日本薬学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001206129398144
-
- NII論文ID
- 130004756442
-
- NII書誌ID
- AN00284903
-
- COI
- 1:STN:280:DC%2BC2cfovVOhtQ%3D%3D
-
- ISSN
- 13475231
- 00316903
-
- NDL書誌ID
- 025628668
-
- PubMed
- 24989473
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可