書誌事項
- タイトル別名
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- Activation of Cellular Defense Mechanism by Organic-Inorganic Hybrid Molecules
- Symposium Review : 有機-無機ハイブリッド分子による生体防御系の活性化
- Symposium Review : ユウキ-ムキ ハイブリッド ブンシ ニ ヨル セイタイ ボウギョケイ ノ カッセイカ
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抄録
Organic-inorganic hybrid molecules can exhibit biological activities by controlling the activities of their individual components. These molecules can be applied as seed/lead compounds in drug development, and can be used as molecular probes in chemical biology for the elucidation of the molecular mechanisms of biological systems. In this review, we introduce copper diethyldithiocarbamate (Cu10), a copper complex, as a compound that activates nuclear factor erythroid 2-related factor 2 (Nrf2) and induces metallothionein, which are the key cellular defense factors against toxic metals and oxidative stress in vascular endothelial cells. It was found that neither the complexes with the same ligand and other metal ions (including zinc and iron) nor the ligand alone was inactive. Therefore, both copper ion and the ligand of Cu10 are essential components for the biological functioning of the complex. In addition, Cu10 may be useful in clarifying the molecular mechanism underlying metallothionein induction in vascular endothelial cells.<br>
収録刊行物
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- 薬学雑誌
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薬学雑誌 134 (7), 813-815, 2014-07-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001206129416064
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- NII論文ID
- 130004756450
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- NII書誌ID
- AN00284903
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- COI
- 1:STN:280:DC%2BC2cfovVOhtA%3D%3D
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 025628652
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- PubMed
- 24989472
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可