ADLib System for Rapid and Flexible Design of Monoclonal Antibodies

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Other Title
  • ADLibシステムを用いたモノクローナル抗体の迅速作製
  • 誌上シンポジウム ADLibシステムを用いたモノクローナル抗体の迅速作製
  • シジョウ シンポジウム ADLib システム オ モチイタ モノクローナル コウタイ ノ ジンソク サクセイ

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Abstract

  Monoclonal antibodies (MAbs) have been utilized as research tools, as diagnostic reagents, and for antibody medicine. The preparation of MAbs involves laborious processes and normally takes months. Here we describe an ex vivo B cell-based antibody display system called the ADLib (Autonomously Diversifying Library) system, which enables us to select chicken B cell clones producing antibody against antigens of interest in a couple of weeks. The ADLib system is applicable to self- or highly conserved antigens, polysaccharide chains, peptides, and haptens.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 127 (1), 81-89, 2007-01-01

    The Pharmaceutical Society of Japan

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