放射線障害防護薬剤に関する研究(第22報)放射線皮膚障害に対する各種含イオウ化合物の防護効果について

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タイトル別名
  • Studies on Chemical Protectors against Radiation. XXII. Protective Effect of Various Sulfur Containing Compounds on Skin Injury induced by X-Irradiation
  • 放射線障害防護薬剤に関する研究-22-放射線皮膚障害に対する各種含イオン化合物の防護効果について
  • ホウシャセン ショウガイ ボウゴ ヤクザイ ニカンスルケンキュウ 22 ホウシ

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説明

The assay for potency was carried out by use of 35 kinds of sulfur containing compounds in order to investigate useful protective drugs for the relief of skin injury caused by irradiation and to elucidate the relationship between their chemical structures and potency manifestation. The protective potency was determined after the irradiation of 1200 R on mice by use of 30 kVp of soft X-ray. In derivatives such as cysteamine, cysteine, thiourea, and isothiourea, a strong protective potency was observed and this potency was enhanced in compounds on which SH-groups are released or apt to be released from a chemical structural point of view. In dithiocarbamates, protective potency was also detected.

収録刊行物

  • 薬学雑誌

    薬学雑誌 102 (8), 774-780, 1982

    公益社団法人 日本薬学会

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