The Basic Study for Analysis of β-Receptor Blocking Drugs by Gas Chromatography
Bibliographic Information
- Other Title
-
- ガスクロマトグラフィーによるβ-受容体遮断剤の分析に関する基礎的研究
- ガス クロマトグラフィー ニ ヨル ベータ ジュヨウタイ シャダンザイ ノ
- The Basic Study for Analysis of β-Receptor Blocking Drugs by Gas Chromatography
Search this article
Abstract
As the basic study of therapeutic drug monitoring (TDM) of β-receptor blocking drugs (β-blockers) by gas chromatography, retention indices were accumulated, and selectivity and sensitivity were compared by flame ionization detector (FID), nitrogen-phosphorus detector (NPD) and electron capture detector (ECD). Retention indices of 15 kinds of β-blockers and those trifluoroacetyl derivative (TFA deriv.) were 2076-3336, 1976-2754 (TFA deriv.) on weakly polar column (OV-17), and 1826-2815, 1860-2329 (TFA deriv.) on nonpolar column (OV-101). Under the same conditions, retention indices of 19 kinds of concurrent medication were also accumulated as reference materials for TDM. Selectivity was shown by peak area ratio of β-blockers to n-paraffins. Selectivity of NPD was almost 2×104 times that of FID. Detectable limits were 10 ng by FID, 0.1-1 ng by NPD and 0.01-0.1 ng (TFA deriv.) by ECD. NPD and ECD showed good selectivity and sensitivity for gas chromatographic analysis of β-blockers.
Journal
-
- YAKUGAKU ZASSHI
-
YAKUGAKU ZASSHI 105 (12), 1179-1183, 1985
The Pharmaceutical Society of Japan
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390001206153470464
-
- NII Article ID
- 130007275242
- 110003649581
-
- NII Book ID
- AN00284903
-
- ISSN
- 13475231
- 00316903
-
- NDL BIB ID
- 3074268
-
- Data Source
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- Abstract License Flag
- Disallowed