書誌事項
- タイトル別名
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- Competitive Binding of Some Alkyl p-Hydroxybenzoates to Human Estrogen Receptor α and β
- パラオキシ アンソクコウサン エステルルイ ノ ヒトエストロゲン ジュヨウタイ アルファ ト ベータ ケツゴウ サヨウ
- Competitive Binding of Some Alkyl p-Hydroxybenzoates to Human Estrogen Receptor α and β
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抄録
Alkyl p-hydroxybenzoates such as isobutyl p-hydroxybenzoate (PHBA-iBu), butyl p-hydroxybenzoate (PHBA-nBu), isopropyl p-hydroxybenzoate (PHBA-iPr), propyl p-hydroxybenzoate (PHBA-nPr), ethyl p-hydroxybenzoate (PHBA-Et), and methyl p-hydroxybenzoate (PHBA-Me) are widely used as preservatives, stabilizers and antiseptics for medical supplies, cosmetics, foodstuffs etc. We determined the binding affinity of alkyl p-hydroxybenzoates to human estrogen receptor α (ERα) and β (ERβ) by non-RI receptor binding assays. PHBA-iBu had a high binding affinity for ERα (IC50 : 6.0×10-6M, the relative binding affinity (RBA) : 0.267) and ERβ (IC50 : 5.0×10-6M, RBA : 0.340). These IC50 values and RBA were almost the same as those of bisphenol A. The ranking of the estrogenic potency of alkyl p-hydroxybenzoates for both ERs is different; that is, PHBA-iBu>PHBA-nBu≒PHBA-iPr≒PHBA-nPr>PHBA-Et»PHBA-Me. Alkyl p-hydroxybenzoates bound with equal relative affinity to both ERα and β proteins. Alkyl p-hydroxybenzoate having a long alkyl side-chain showed a high affinity for ERα and β. These findings suggest that p-hydroxybenzoates may be endocrine disruptors.
収録刊行物
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- 薬学雑誌
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薬学雑誌 120 (12), 1429-1433, 2000
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001206153653760
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- NII論文ID
- 130007275603
- 110003648796
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
- http://id.crossref.org/issn/00316903
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- NDL書誌ID
- 5601148
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可