Researches on Chemotherapeutic Drugs against Viruses. VI

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タイトル別名
  • Researches on Chemotherapeutic Drugs against Viruses. IX
  • Syntheses and Antiviral Effects of 3-Phenylazo-4-hydroxynaphthalene Sulfonamide and Its Derivatives

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1) 3-Phenylazo-4-hydroxynaphthalene sulfonamide and its derivatives were synthesized by diazotizing aniline and its ring-substitutes, and coupling the resulting diazonium compounds with 4-hydroxynaphthalene sulfonamide and its N1-substitutes.<br>2) These compounds were examined as to their activities in vitro against the Nakayama strain of Encephalitis japonica.<br>3) Among these compounds, o- and p-[3-(p-methylphenylazo)-4-hydroxynaphthalenesulfonamido]-benzoic acid possessed the effects approximately equal to that of p-(3-phenylao-4-aminonaphthalenesulf onamido)-benzoic acid, which were proved to possess the strongest effects in vitro and in vivo among all known substances active against neurotropic virus

収録刊行物

  • 薬学雑誌

    薬学雑誌 72 (10), 1354-1359, 1952

    公益社団法人 日本薬学会

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