Desensitizing Function of Calcium Mobilized by the Postsynaptic Neuronal-Type Nicotinic Acetylcholine Receptors at the Neuromuscular Junction
Bibliographic Information
- Other Title
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- 神経型ニコチン性アセチルコリン受容体のCa<SUP>2+</SUP>を介した脱感作機能の解明
- 神経型ニコチン性ァセチルコリン受容体のCa2+を介した脱感作機能の解明
- シンケイガタ ニコチンセイ ァセチルコリン ジュヨウタイ ノ Ca2 オ カイシタ ダッカンサ キノウ ノ カイメイ
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Abstract
Neuronal-type nicotinic acetylcholine receptors (N-nAChR) are co-localized with muscle-type (M-)nAChR in the postjunctional endplate membrane of adult skeletal muscle fibers. The postsynaptic desensitizing functions of the N-nAChR at the neuromuscular junction and at single skeletal muscle cells have been investigated using aequorin luminescence and fluorescence confocal imaging. A biphasic elevation of local intracellular Ca2+ is elicited by prolonged nicotinic action at the mouse muscle endplates. The contractile fast and noncontractile slow Ca2+ components are operated by postsynaptic M- and colocalized N-type nAChR, respectively. We have named the latter slow one RAMIC (receptor-activity modulating intracellular Ca2+). The N-nAChR are activated by nicotine and choline, and RAMIC are antagonized by methyllycaconitine and dihydro-β-erythroidine. Neuromuscular functions may be regulated by a dual nAChR system to maintain the normal postsynaptic excitability. Certain N-nAChR may be also endowed with the same functional role in the central nervous system.
Journal
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- YAKUGAKU ZASSHI
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YAKUGAKU ZASSHI 119 (1), 1-15, 1999
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001206154082560
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- NII Article ID
- 110003648709
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- NII Book ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL BIB ID
- 105534
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed