エチルセルロースを結合剤として用いたタルク積層法によるイブプロフェンの溶出制御技術

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タイトル別名
  • Controlled Release Dosage Form of Ibuprofen Which was Layered by Talc with Ethylcellulose Binder
  • エチル セルロース オ ケツゴウザイ ト シテ モチイタ タルク セキソウホウ

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説明

We studied the controlled release dosage form of ibuprofen which was layered by talc with an ethylcellulose (EC) binder. In this dosage form, the amount of EC was variable in the range of 4.1-6.0 g according to the operating conditions (e.g. slit air temperature). However the release rate of ibuprofen was changed according to these conditions. It was, therefore, difficult to assure the reproducible productivity of sustained-release granules of ibuprofen. We designed formulations of EC binder solutions ; EC-ethanol, EC-ethanol-water and EC-ethanol-water-hydroxypropylmethylcellulose (HPMC), and investigated the release rate of ibuprofen which was prepared by each formulation. The results showed that the release rate of ibuprofen was not changed in the range of 4.2-10.3 g of the amount of EC used in the EC-ethanol-water-HPMC formulation.

収録刊行物

  • 薬学雑誌

    薬学雑誌 118 (2), 72-77, 1998

    公益社団法人 日本薬学会

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