抗潰瘍剤の研究(第1報)各種生薬のメタノール及び水抽出エキスの抗潰瘍作用

DOI Web Site Web Site 被引用文献1件

書誌事項

タイトル別名
  • Studies on Antiulcer Agents. I. The Effects of Various Methanol and Aqueous Extracts of Crude Drugs on Antiulcer Activity
  • 抗潰瘍剤の研究-1-各種生薬のメタノール及び水抽出エキスの抗潰瘍作用
  • コウ カイヨウザイ ノ ケンキュウ 1 カクシュ ショウヤク ノ メタノール

この論文をさがす

説明

The antiulcer activities of 59 methanol and aqueous extracts obtained from 59 crude drugs on the ethanol-HCl-induced ulceration in rats were investigated. Among them 15 extracts were selected and they were further examined for their effects on indomethacin-, aspirin- and the water-immersion stress-induced ulcer. From these results, the methanol extract of root of Iris germanica was found to show potent antiulcer activities. The above methanol extract was separated into 3 portions by solvent extration, and the ether soluble portion was fractionated into 5 fractions (1 to 5) by chromatography. Fractions 4 and 5 showed significant antiulcer activities. Fraction 4 was further purified and the obtained γ-irigermanal exhibited a potent antiulcer activity. However, further investigations are required to understand the mechanism.

収録刊行物

  • 薬学雑誌

    薬学雑誌 114 (12), 980-994, 1994

    公益社団法人 日本薬学会

被引用文献 (1)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ